Complement C5a

The minor fragment formed when C5 convertase cleaves C5 into C5a and COMPLEMENT C5B. C5a is a 74-amino-acid glycopeptide with a carboxy-terminal ARGININE that is crucial for its spasmogenic activity. Of all the complement-derived anaphylatoxins, C5a is the most potent in mediating immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE), smooth MUSCLE CONTRACTION; HISTAMINE RELEASE; and migration of LEUKOCYTES to site of INFLAMMATION.

Also Known As:

Complement 5a; C5a Complement; Complement Component 5a; C5a, Complement; Complement, C5a; Component 5a, Complement

Pharmalogical Action Categories:

Immunologic Factors

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Immunoproteins: 43
      - Complement System Proteins: 33379
        Anaphylatoxins: 563
        Complement C5a: 190
        Complement C5: 270
        Complement C5a: 190

Máté Aller Selected Research

Máté Aller Research Topics

Disease

Drug/Important Bio-Agent (IBA)